Why the study?
Does myocardial infarction-induced heart failure alter interstitial norepinephrine concentration and uptake in skeletal muscle during sympathetic stimulation in rats?
Population
Rats 8-10 weeks after induction of myocardial infarction (MI) and control rats
Comparison
Electrical stimulation of lumbar sympathetic… vs Control rats without MI
Design
Preclinical
Authors
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Impaired NE uptake-1 may elevate interstitial norepinephrine in HF skeletal muscle; animal data leave open human relevance.
Does myocardial infarction-induced heart failure alter interstitial norepinephrine concentration and uptake in skeletal muscle during sympathetic stimulation in rats?
Heart failure increases interstitial norepinephrine concentrations in skeletal muscle during sympathetic stimulation, partly due to reduced NE uptake-1.
Xing et al. (2007) studied this question.
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