Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 17, 2004AJP Heart and Circulatory Physiology

Infarction alters both the distribution and noradrenergic properties of cardiac sympathetic neurons

View Full Paper
Ask AI
Bookmark
Share

Population

Control and myocardial infarction (MI) rats

Comparison

Myocardial infarction (MI) vs Control rats

Design

Preclinical

Authors

WLWěi LiDKDavid KnowltonDWDonna M. Van Winkle

Discussion

Loading...

Member takes

Overview

Regional sympathetic remodeling post-MI may promote arrhythmias; hypothesis-generating in rodents and requires human validation.

Structured PICO

P
Population
Control and myocardial infarction (MI) rats
I
Intervention
Myocardial infarction (MI)
C
Comparator
Control rats
O
Outcome
Changes in sympathetic innervation, including tyrosine hydroxylase (TH) expression, norepinephrine transporter (NET) binding sites, and mRNA levels in the heart and stellate gangliasurrogate

Myocardial infarction induces regional alterations in cardiac sympathetic innervation, characterized by increased tyrosine hydroxylase expression at the base of the heart and denervation in the left ventricle, which may contribute to post-MI arrhythmias.

Cite This Study

Li et al. (2004) studied this question.

synapsesocial.com/papers/6a70b479f44fa9f079de64d3https://doi.org/10.1152/ajpheart.00768.2003
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute and chronic effects of transient myocardial ischemia on sympathetic nerve activity, density, and norepinephrine content1995 · 70 citations
  2. 2Denervation supersensitivity of refractoriness in noninfarcted areas apical to transmural myocardial infarction.1987 · 157 citations
  3. 3Correlation between the response of the heart to sympathetic stimulation and the release of endogenous catecholamines into the coronary sinus of the dog.1975 · 149 citations
  4. 4Time course of denervation of efferent sympathetic and vagal nerves after occlusion of the coronary artery in the canine heart.1988 · 126 citations
  5. 5Involvement of Leukemia Inhibitory Factor in the Increases in Galanin and Vasoactive Intestinal Peptide mRNA and the Decreases in Neuropeptide Y and Tyrosine Hydroxylase mRNA in Sympathetic Neurons After Axotomy1996 · 122 citations