Why the study?
Does the use of measured plasma concentrations improve the precision and accuracy of pharmacokinetic forecasting compared to relying only on patient features?
Comparison
Use of measured plasma concentrations for… vs No measured CPs or reliance only on observable…
Design
Other
Authors
Loading...
Measured concentrations may sharpen digoxin PK forecasts over demographics alone; hypothesis-generating for TDM utility pending outcome trials.
Does the use of measured plasma concentrations improve the precision and accuracy of pharmacokinetic forecasting compared to relying only on patient features?
Incorporating previously observed plasma concentrations significantly improves the accuracy and precision of pharmacokinetic forecasting compared to relying solely on patient demographics.
Sheiner et al. (1979) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: