February 1, 1996Journal of Lipid ResearchOpen Access

A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice

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Population

Mice embryos (apoB-/-, apoB+/-, and wild-type)

Comparison

Disruption of the apoB gene (apoB-/-) vs Wild-type or apoB+/- embryos

Design

Preclinical

Authors

RFRobert V. FareseBroad Institute SCSylvaine CasesCentre National de la Recherche Scientifique SRS L RulandGladstone Institutes

Discussion

Member takes

Implication

ApoB is essential for murine embryonic lipid transport and viability; leaves open relevance to human development or therapies.

Structured PICO

Population

Mice embryos (apoB-/-, apoB+/-, and wild-type)

Intervention

Disruption of the apoB gene (apoB-/-)

Comparator

Wild-type or apoB+/- embryos

Outcome

Embryonic lethality and lipid transport (accumulation of intracellular lipid droplets, absence of lipoproteins from the secretory pathway, reduced concentrations of cholesterol and alpha-tocopherol)surrogate

ApoB plays an essential role in the transport of lipid nutrients to the developing mouse embryo via yolk sac-mediated synthesis and secretion of apoB-containing lipoproteins.

Cite This Study

Farese et al. (1996) studied this question.

synapsesocial.com/papers/6a73f689f2548bdd13cde9df https://doi.org/10.1016/s0022-2275(20)37621-5

View Full Paper

Ask AI

Bookmark

A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider