January 1, 1991Clinical Pharmacology & Therapeutics

Population dose versus response of betaxolol and atenolol: A comparison of potency and variability

View Full Paper

Ask AI

Bookmark

Why the study?

Does betaxolol compared to atenolol differ in dose-response potency and variability for blood pressure reduction in patients with mild to moderate essential hypertension?

Population

140 patients with mild to moderate essential hypertension and a supine diastolic blood pressure of 95 to 115…

Comparison

Betaxolol in a dose-escalation manner, increased… vs Atenolol in a dose-escalation manner, increased…

Design

RCT, randomized, double-blind (following a single-blind placebo washout)

Follow-up

Up to 24 weeks

Authors

NSNancy C. SambolUniversity of California, San Francisco LSLewis B. SheinerRoche (Switzerland)

Discussion

Member takes

Implication

Betaxolol reaches near-maximal BP reduction at lowest dose unlike graded atenolol response; extends dose-response profiling of beta-blockers in essential hypertension.

Structured PICO

Does betaxolol compared to atenolol differ in dose-response potency and variability for blood pressure reduction in patients with mild to moderate essential hypertension?

Population

140 patients with mild to moderate essential hypertension and a supine diastolic blood pressure of 95 to 115 mm Hg at the end of a 4-week single-blind placebo washout phase

Intervention

Betaxolol in a dose-escalation manner (5 mg, 10 mg, and 20 mg), increased every 4 weeks if supine diastolic blood pressure remained >90 mm Hg, followed by 12 weeks on the final dose and a 2-week placebo phase

Comparator

Atenolol in a dose-escalation manner (25 mg, 50 mg, and 100 mg), increased every 4 weeks if supine diastolic blood pressure remained >90 mm Hg, followed by 12 weeks on the final dose and a 2-week placebo phase

Outcome

Dose-response curve and maximum effect on supine diastolic blood pressuresurrogate

Betaxolol and atenolol achieve similar maximum blood pressure reductions, but betaxolol reaches near-maximum efficacy at its lowest starting dose compared to the graded response of atenolol.

Cite This Study

Sambol et al. (1991) studied this question.

synapsesocial.com/papers/6a73f73cb7b02007e5a8c5ec https://doi.org/10.1038/clpt.1991.5

View Full Paper

Ask AI

Bookmark

Implication

Betaxolol reaches near-maximal BP reduction at lowest dose unlike graded atenolol response; extends dose-response profiling of beta-blockers in essential hypertension.

Population dose versus response of betaxolol and atenolol: A comparison of potency and variability

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Population dose versus response of betaxolol and atenolol: A comparison of potency and variability

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider