Population
Recombinant human cardiac L-type Ca(2+) channel alpha(1C) subunit (hHT isoform) expressed in HEK 293 cells
Comparison
Hypoxia and selective restriction of the spliced… vs Other naturally occurring splice variants
Design
Preclinical
Authors
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Maps oxygen-sensing domain in an ion channel; hypothesis-generating for hypoxia mechanisms and requires mammalian validation.
This study provides the first identification of a specific 39-amino acid structural region in an ion channel required for sensing changes in oxygen tension.
Fearon et al. (2000) studied this question.
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