Why the study?
Does targeted deletion of p53 improve survival and prevent cardiac rupture after myocardial infarction in mice?
Population
57 male mice with anterior myocardial infarction created by ligating the left coronary artery.
Comparison
Targeted deletion of the p53 gene vs Sibling wild-type (p53+/+) mice
Design
Preclinical
Follow-up
7 days
Authors
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Does not support p53 inhibition after MI in patients; leaves open translation of reduced rupture in p53(+/-) mice.
Does targeted deletion of p53 improve survival and prevent cardiac rupture after myocardial infarction in mice?
Targeted deletion of p53 in mice reduces apoptosis and prevents cardiac rupture after myocardial infarction, suggesting p53 inhibition as a potential therapeutic strategy.
Matsusaka et al. (2006) studied this question.
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