Population
NIH 3T3 cells
Design
Preclinical
Authors
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No immediate clinical implications from this animal model; leaves open therapeutic targeting of mRNA stability pathways in human disease.
The study proposes an integrated model of mRNA turnover control where stabilizing and destabilizing AU-binding proteins compete under the control of independent phosphokinase signaling pathways.
Ming et al. (2001) studied this question.
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