Key result
AUF1 binds to an AU-rich element in the 3' untranslated region of Interleukin-6 mRNA in vivo, cooperating with a stem-loop structure to promote its degradation.
Population
In vitro cell models (implied by cell extracts, RNA interference, and transfections)
Comparison
Overexpression of myc-tagged AUF1 p37 and p42… vs Control conditions
Design
Preclinical
Authors
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Identifies a novel post-transcriptional regulatory mechanism for IL-6; leaves open whether targeting this.
The study identifies that IL-6 mRNA degradation is mediated by the RNA-binding protein AUF1 interacting with a specific AU-rich element and a stem-loop structure in the 3' untranslated region.
Paschoud et al. (2006) studied this question. AUF1 overexpression/suppression and MG132 was evaluated on Interleukin-6 mRNA stability and degradation. AUF1 binds to an AU-rich element in the 3' untranslated region of Interleukin-6 mRNA in vivo, cooperating with a stem-loop structure to promote its degradation.
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