What question did this study set out to answer?

To evaluate the impact of lifelong angiotensin II type 1 receptor blockade with fonsartan on survival, cardiac remodeling, and vascular function in stroke-prone hypertensive rats.

April 1, 2000Hypertension

Long-Term Angiotensin II Type 1 Receptor Blockade With Fonsartan Doubles Lifespan of Hypertensive Rats

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To evaluate the impact of lifelong angiotensin II type 1 receptor blockade with fonsartan on survival, cardiac remodeling, and vascular function in stroke-prone hypertensive rats.
Allotted 90 one-month-old stroke-prone spontaneously hypertensive rats (SHR-SP) to receive either fonsartan (10 mg·kg⁻¹·d⁻¹) or placebo via drinking water.
Assessed lifespan as the primary endpoint alongside left ventricular hypertrophy, cardiac metabolism, endothelial function, and tissue expression of eNOS and ACE.
Fonsartan doubled the lifespan of SHR-SP to 30 months, achieving survival rates equivalent to normotensive Wistar-Kyoto rats.
At 15 months, when approximately 80% of placebo-treated controls had died, fonsartan-treated rats showed complete prevention of left ventricular hypertrophy and significant improvements in cardiac and endothelial function.
Vascular and survival benefits were accompanied by increased endothelial nitric oxide synthase expression in cardiac and carotid tissues alongside marked reductions in tissue ACE expression and activity.

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Implication

Supports early ARB investigation in experimental hypertension; leaves open human translation and need for clinical trials.

Cite This Study

Linz et al. (2000) studied this question.

synapsesocial.com/papers/6a742e0292beb6febf989500 https://doi.org/10.1161/01.hyp.35.4.908

Topics

Hypertension management

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Long-Term Angiotensin II Type 1 Receptor Blockade With Fonsartan Doubles Lifespan of Hypertensive Rats

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Implication

Cite This Study

Topics

Long-Term Angiotensin II Type 1 Receptor Blockade With Fonsartan Doubles Lifespan of Hypertensive Rats

Key Points

Discussion

Implication

Cite This Study

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