Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1998HypertensionOpen Access

AT2Receptor Stimulation Increases Aortic Cyclic GMP in SHRSP by a Kinin-Dependent Mechanism

View Full Paper
Ask AI
Bookmark
Share

Population

Adult SHRSP (stroke-prone spontaneously hypertensive rats)

Comparison

Angiotensin II for 4 hours, with or without… vs Vehicle (0.9% NaCl IV)

Design

Preclinical

Follow-up

4 hours

Authors

PGPeter GohlkeShanghai Medical College of Fudan UniversityCPChristiane PeesMedical University of ViennaTUThomas UngerGeneral Cardiology

Discussion

Loading...

Member takes

Implication

Supports AT2-bradykinin-NO cGMP pathway in hypertensive rat models; leaves open human therapeutic relevance.

Structured PICO

P
Population
Adult SHRSP (stroke-prone spontaneously hypertensive rats)
I
Intervention
Angiotensin II (30 ng/kg per min IV) for 4 hours, with or without pretreatment with losartan (100 mg/kg PO), PD 123319 (30 mg/kg IV), icatibant (500 microg/kg IV), L-NAME (1 mg/kg IV), or minoxidil (3 mg/kg IV)
C
Comparator
Vehicle (0.9% NaCl IV)
O
Outcome
Aortic cGMP content and plasma ANG II levels at 4 hourssurrogate

Angiotensin II increases aortic cGMP in stroke-prone spontaneously hypertensive rats via an AT2 receptor-mediated mechanism dependent on bradykinin and nitric oxide.

Cite This Study

Gohlke et al. (1998) studied this question.

synapsesocial.com/papers/6a17533e7c24967ccc5df315https://doi.org/10.1161/01.hyp.31.1.349

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Losartan on Angiotensin and Bradykinin Peptides and Angiotensin-Converting Enzyme1995 · 146 citations
  2. 2Metabolism and production of angiotensin I in different vascular beds in subjects with hypertension.1990 · 191 citations
  3. 3Regression of left ventricular hypertrophy as a surrogate end-point for morbid events in hypertension treatment trials1996 · 177 citations
  4. 4Cardiac and Vascular Effects of Long-term Losartan Treatment in Stroke-Prone Spontaneously Hypertensive Rats1996 · 93 citations
  5. 5Release of nitric oxide by angiotensin‐(1–7) from porcine coronary endothelium: implications for a novel angiotensin receptor1994 · 240 citations