Methodological and Conceptual Concerns Regarding the 24‐h Glycaemia/C‐Peptide Ratio as a Novel Insulin Sensitivity Index

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Key Points

The aim is to address the methodological and conceptual issues related to using the 24-hour glycaemia/C-peptide ratio as an insulin sensitivity index.
Review of existing literature on glycaemia and C-peptide measurements.
Analysis of methodological frameworks for insulin sensitivity indices.
Evaluation of the conceptual basis for using the 24-hour ratio.
Identified inconsistencies in measurement techniques affecting the ratio's reliability.
Highlighted potential misinterpretations of the ratio in clinical settings.
Proposed alternative approaches for assessing insulin sensitivity.

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Conceptual concerns about the 24-hour glycaemia/C-peptide ratio as a measure of insulin sensitivity, highlighting implications for clinical practice.

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Zaitoon et al. (2026) studied this question.

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