Why the study?
Does altered end-tidal PCO2 (hypocapnia or hypercapnia) affect the muscle sympathetic nerve activity response to orthostatic stress?
Population
Subjects undergoing orthostatic stress testing (head-up tilt)
Comparison
Clamping end-tidal PCO2 at hypercapnic and… vs Normocapnic condition
Design
Other
Authors
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Hypocapnia may augment sympathetic compensation to orthostasis; hypothesis-generating for CO2-autonomic interactions, with no immediate clinical implications.
Does altered end-tidal PCO2 (hypocapnia or hypercapnia) affect the muscle sympathetic nerve activity response to orthostatic stress?
The muscle sympathetic nerve activity response to orthostatic stress varies inversely with end-tidal PCO2 levels, suggesting that hypercapnia sustains blood pressure via augmented cardiac output and diminishes the sympathetic response.
Shoemaker et al. (2001) studied this question.
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