Population
Ground squirrels (Spermophilus tridecemlineatus), n=8
Comparison
Hibernation induced by placement in an… vs Cold-adapted active animals that were not…
Design
Preclinical
Authors
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Hibernation models endogenous tolerance to ischemic CBF levels; leaves open translation to human neuroprotection strategies.
Hibernation in ground squirrels reduces cerebral blood flow to ischemic levels without causing neuropathological damage, providing a model for natural tolerance to cerebral ischemia.
Frerichs et al. (1994) studied this question.
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