Why the study?
Regulators of fibroblast progression through polarization stages during myofibroblast differentiation remain poorly understood.
Population
Primary murine cardiac fibroblasts and knockout mouse models undergoing transverse aortic constriction
Comparison
Combined ablation of Ror1/2 vs control
Design
Preclinical cell culture and knockout mouse study
Authors
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Hypothesis-generating for planar cell polarity in cardiac fibrosis; leaves open therapeutic relevance in human heart failure.
Ror1/2 receptors are essential for cardiac myofibroblast differentiation and adaptive remodeling in response to pressure overload in mice.
Chavkin et al. (2021) studied this question.
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