Why the study?
Cardiac fibrosis drives heart failure via myofibroblast differentiation through distinct polarization stages, but the regulators controlling this progression are poorly understood.
Population
Primary murine cardiac fibroblasts and knockout mice undergoing transverse aortic constriction surgery
Comparison
Ror1/2 ablation vs baseline or control conditions
Design
Preclinical cell culture and mouse model study
Authors
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Ror1/2 may represent antifibrotic targets; animal data leave open clinical relevance in human heart failure.
Ror1/2 receptors are essential for cardiac myofibroblast differentiation and adaptive remodeling in response to pressure overload in a murine model.
Chavkin et al. (2021) studied this question.
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