Why the study?
No therapies exist to reverse right ventricular failure, and the molecular mechanisms driving it remain poorly studied despite ROR2 upregulation in human disease.
Does ROR2 modulation affect proteostasis and cardiac function in models of right ventricular failure?
Population
Neonatal rat ventricular myocytes and mice in a pulmonary artery banded pressure overload model
Comparison
AAV9-mediated ROR2 overexpression or knockdown vs control
Design
Preclinical in vitro and in vivo mechanistic study
Authors
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ROR2 modulation in NRVMs is hypothesis-generating for RVF mechanisms; leaves open any therapeutic role in humans.
Does ROR2 modulation affect proteostasis and cardiac function in models of right ventricular failure?
ROR2 drives right ventricular failure pathogenesis through proteostatic disruption, highlighting it as a potential therapeutic target.
Hartman et al. (2025) studied this question.
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