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November 10, 2016Journal of Cardiovascular Electrophysiology

Outcome of Patients With Cardiac Sarcoidosis Who Received Cardiac Resynchronization Therapy: Comparison With Dilated Cardiomyopathy Patients

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Why the study?

Does cardiac resynchronization therapy (CRT) result in different rates of major adverse cerebral and cardiovascular events (MACCE) in patients with cardiac sarcoidosis compared to those with dilated cardiomyopathy?

Population

40 patients receiving cardiac resynchronization therapy, including 11 consecutive patients with cardiac…

Comparison

Cardiac resynchronization therapy in patients… vs Cardiac resynchronization therapy in patients…

Design

Cohort

Follow-up

Mean 465 ± 383 days for CS and 729 ± 393 days for DCM

Authors

KYKunio YufuHKHidekazu KondoTSTetsuji Shinohara

Discussion

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Member takes

Overview

CRT outcomes in cardiac sarcoidosis warrant caution; small retrospective comparison leaves open equivalence to dilated cardiomyopathy.

Structured PICO

Does cardiac resynchronization therapy (CRT) result in different rates of major adverse cerebral and cardiovascular events (MACCE) in patients with cardiac sarcoidosis compared to those with dilated cardiomyopathy?

P
Population
40 patients receiving cardiac resynchronization therapy (CRT), including 11 consecutive patients with cardiac sarcoidosis (CS) (mean age 66 ± 8.0 years, 8 females) and 29 patients with dilated cardiomyopathy (DCM) (mean age 70 ± 8.9 years, 9 females).
I
Intervention
Cardiac resynchronization therapy (CRT) in patients with cardiac sarcoidosis (CS)
C
Comparator
Cardiac resynchronization therapy (CRT) in patients with dilated cardiomyopathy (DCM)
O
Outcome
Incidence of major adverse cerebral and cardiovascular events (MACCE)composite

Patients with cardiac sarcoidosis receiving CRT have significantly worse long-term outcomes (higher MACCE rates) compared to those with dilated cardiomyopathy, suggesting caution in its application for this population.

Cite This Study

Yufu et al. (2016) studied this question.

synapsesocial.com/papers/6a744787b06f632524092e24https://doi.org/10.1111/jce.13119
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Response to preventive cardiac resynchronization therapy in patients with ischaemic and nonischaemic cardiomyopathy in MADIT-CRT2010 · 148 citations
  2. 2Effect of Corticosteroid Therapy on Long-Term Clinical Outcome and Left Ventricular Function in Patients With Cardiac Sarcoidosis2015 · 91 citations
  3. 3The Work‐Up and Management of Patients with Apparent or Subclinical Cardiac Sarcoidosis: With Emphasis on the Associated Heart Rhythm Abnormalities2009 · 206 citations
  4. 4Cardiac sarcoid: a clinicopathologic study of 84 unselected patients with systemic sarcoidosis.1978 · 990 citations
  5. 5Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events2009 · 3,176 citations