October 1, 1993CirculationOpen Access

Ionic mechanisms of electronic inhibition and concealed conduction in rabbit atrioventricular nodal myocytes.

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Population

Single myocytes isolated from the rabbit atrioventricular node, and a mathematical model of the AV nodal…

Design

Preclinical

Authors

YLYe LiuLiaoning University of Traditional Chinese Medicine WZWeizhong ZengElectrophysiology MDMario DelmarElectrophysiology

Discussion

Member takes

Implication

May explain concealed AV conduction on ECG; hypothesis-generating for human arrhythmia mechanisms.

Structured PICO

Population

Single myocytes isolated from the rabbit atrioventricular (AV) node, and a mathematical model (Hodgkin-Huxley type) of the AV nodal myocyte

Intervention

Interpolation of a conditioning pulse of depolarizing but subthreshold current, and superfusion with tetrodotoxin (30 microM)

Outcome

Failure of subsequent activation and transient reduction of excitabilitysurrogate

Electrocardiographic manifestations of concealed AV conduction are likely the result of electrotonic inhibition of excitability secondary to a transient decrease in the transient calcium current (ICa.T).

Cite This Study

Liu et al. (1993) studied this question.

synapsesocial.com/papers/6a7447e217dd9a89f6092f64 https://doi.org/10.1161/01.cir.88.4.1634

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Ionic mechanisms of electronic inhibition and concealed conduction in rabbit atrioventricular nodal myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ionic mechanisms of electronic inhibition and concealed conduction in rabbit atrioventricular nodal myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider