Why the study?
Does a single oral dose of atropine impair physiological, psychological, and psychomotor functions in healthy male volunteers?
Does a single oral dose of atropine impair physiological, psychological, and psychomotor functions in healthy male volunteers?
A single oral dose of atropine causes significant, dose-related CNS impairment and peripheral antimuscarinic effects in healthy male volunteers.
Oral atropine impairs CNS function dose-dependently; extends central anticholinergic data to oral dosing and warrants clinical caution.
Eight healthy male volunteers received double-blind and cross-over placebo or atropine (0.85 or 1.7 mg). Various physiological, psychological and psychomotor measurements were made before a single oral dose and 1, 2 and 4 hrs after it. Typical peripheral antimuscarinic effects were found after atropine, maximally at 2-4 hrs. Atropine impaired flicker recognition, reaction time, short-time, short-term memory, coordination, time anticipation and standing steadiness. The CNS-impairment was maximal at 1 hr and dose-related in most instances.
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Seppαlä et al. (1983) studied this question.
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