Fluorocarbon treatment effectively purifies foot-and-mouth disease virus without loss of infectivity or immunogenicity and enables dissociation of virus-antibody complexes.
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May aid FMDV purification research in animal models; leaves open translation to vaccines or therapies.
Summary Treatment of suspensions of foot-and-mouth disease virus with Arcton eliminates the 7 mμ component without reducing the infectivity titer. The immunogenicity of vaccines prepared from virus suspensions and Arcton-treated suspensions is the same, indicating that there is no loss of 20 mμ component. Neutral mixtures of virus and antiserum can be dissociated with excellent recovery of virus infectivity.
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Brown et al. (1960) studied this question.
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