Key result
The hyper-apolipoprotein B and hypertriglyceridemia phenotype was associated with a significantly higher prevalence of hypertension (OR 3.615) compared to normolipidemic individuals.
Cross-Sectional (n=667)
No
Odds Ratio: 3.615 (95% CI 2.321–5.523)
Absolute Event Rate: 47.8% vs 20.2%
p-value: p=<0.001
Dyslipidemia, particularly hypertriglyceridemia, is strongly associated with a higher prevalence of prehypertension and hypertension, which cumulatively contribute to increased carotid intima-media thickness, a marker of subclinical atherosclerosis.
INTRODUCTION: Like hypertension, prehypertension is associated with cardiovascular disease. AIMS: The aim of this study was to evaluate: a) the prevalence of prehypertension/hypertension in individuals with various dyslipidemic phenotypes; b) the relation between blood pressure (BP) and other risk factors for atherosclerosis; c) atherogenic potential of prehypertension by the assessment of intima-media thickness of the arteria carotis communis (IMT). METHODS: 667 clinically asymptomatic subjects were divided into four dyslipidemic phenotypes (DLP) according to apolipoprotein B (apoB) and triglycerides (TG): DLP1 (n=198, normo-apoB/normo-TG), DLP2 (n=179, normo-apoB/hyper-TG), DLP3 (n=87, hyper-apoB/normo-TG), DLP4 (n=203, hyper-apoB/hyper-TG). DLP1 served as a control group. RESULTS: There was significantly higher prevalence of prehypertension and hypertension in subjects with dyslipidemia (DLP2 43.0%, 41.3%; DLP3 42.5%, 29.9%; DLP4 42.4%, 47.8%) than in normolipidemic individuals (DLP1 32.8%, 20.2%). Systolic and diastolic blood pressure (SBP + DBP) correlated with age, total cholesterol, TG, non-HDL-cholesterol, body mass index and waist circumference; SBP additionally with C-peptide, fasting glycemia; DBP additionally with apoB, homeostasis model assessment (HOMA) and plasminogen activator inhibitor-1. The IMT of hypertensive and of prehypertensive subjects was higher than that of subjects with normal BP in all DLPs. CONCLUSIONS: The prevalence of prehypertension was higher in all dyslipidemic patients. The common prevalence of prehypertension/hypertension was highest in the hypertriglyceridemic subjects. Prehypertensive and hypertensive patients had higher IMT than normotensive individuals in all DLPs.
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Karásek et al. (2012) conducted a cross-sectional in Dyslipidemia (n=667). Dyslipidemia (hyper-apoB/hyper-TG phenotype) vs. Normolipidemic phenotype (normo-apoB/normo-TG) was evaluated on Presence of hypertension (OR 3.615, 95% CI 2.321-5.523, p=<0.001). The hyper-apolipoprotein B and hypertriglyceridemia phenotype was associated with a significantly higher prevalence of hypertension (OR 3.615) compared to normolipidemic individuals.
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