Key result
T allele carriers of the -55CT UCP3 polymorphism exhibited no metabolic response to weight loss induced by a hypocaloric diet rich in polyunsaturated fatty acids.
Why the study?
Does the -55CT polymorphism of the UCP3 gene influence metabolic response and weight loss following a hypocaloric diet rich in polyunsaturated fat in obese patients?
Cohort (n=133)
Does the -55CT polymorphism of the UCP3 gene influence metabolic response and weight loss following a hypocaloric diet rich in polyunsaturated fat in obese patients?
The -55CT polymorphism of the UCP3 gene blunts the metabolic improvements typically seen with weight loss from a polyunsaturated fat-rich hypocaloric diet in obese patients.
May blunt diet-induced metabolic gains in obese T carriers; hypothesis-generating for gene-diet interactions, needs RCTs.
BACKGROUND AND OBJECTIVES: The alteration in the protein expression of UCP3 could reduce energy consumption and increase energy storage as fat. The aim of our study was to investigate the influence of -55CT polymorphism of UCP3 gene in the metabolic response, weight loss and serum levels of adipokines following a hypocaloric diet rich in polyunsaturated fat in obese patients. DESIGN: A sample of 133 obese patients were analyzed prospectively for 3 months. The hypocaloric diet was 1459 kcal, 45.7% carbohydrate, 34.4% from 19.9% lipids and proteins. The fat distribution was, a 21.8% saturated fat, 55.5% monounsaturated and 22.7% of polyunsaturated fat (7 g per day of fatty acids w6, 2 g per day of w -3 and a ratio w6/w3 of 3.5). RESULTS: A total of 100 patients (28 males/72 females) (75.2%) had genotype - 55CC (wild genotype group) and 33 patients (8 males/25 females) (24.8%) -55CT genotype (group mutant genotype). In the wild genotype, body mass index (-2.5 ± 5.3 kg/m²), weight (-4.2 ± 3.7 kg), fat mass (-3,7 ± 3.3 kg), waist circumference (-4.1 ± 2.9 cm), systolic blood pressure (-4.9 ± 10.1 mmHg), total cholesterol levels (- 16.1 ± 23.6 mg / dl), LDL cholesterol (-11.1 ± 26.8 mg/dl), triglycerides (-12.0 ± 46.8 mg/dl), insulin (-1.8 ± 4.5 IU/L), HOMA-R (-0.6 ± 1.5) and leptin (-6.2 ± 8.4 ng/ml) decreased. In the mutant genotype anthropometric parameters were significantly decreased without significant changes in biochemical parameters. CONCLUSION: The T allele carriers of -55CT UCP3 polymorphism exhibit no metabolic response to weight loss induced by a hypocaloric diet rich in polyunsaturated fatty acids.
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Luis et al. (2013) conducted a cohort in Obesity (n=133). -55CT polymorphism of UCP3 gene (mutant genotype) vs. -55CC genotype (wild genotype) was evaluated on Metabolic response, weight loss and serum levels of adipokines. T allele carriers of the -55CT UCP3 polymorphism exhibited no metabolic response to weight loss induced by a hypocaloric diet rich in polyunsaturated fatty acids.
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