Key result
The -55C/T polymorphism of the UCP3 gene was not significantly associated with metabolic syndrome (OR 1.17, 95% CI 0.99-1.38 for wild vs. mutant genotype).
Why the study?
Does the -55C/T polymorphism of the UCP3 gene increase the risk of metabolic syndrome in obese Caucasian patients?
Cross-Sectional (n=817)
Does the -55C/T polymorphism of the UCP3 gene increase the risk of metabolic syndrome in obese Caucasian patients?
Odds Ratio: 1.17 (95% CI 0.99–1.38)
The -55C/T polymorphism of the UCP3 gene is not a major risk factor for metabolic syndrome in obese Caucasian patients, though it may be associated with lower total and LDL cholesterol in those who have the syndrome.
Does not support UCP3 -55C/T genotyping for metabolic syndrome risk assessment in obese Caucasians; leaves open possible lipid associations in affected patients.
BACKGROUND AND AIMS: The relation of -55C/T polymorphism of uncoupling protein 3 (UCP3) with metabolic syndrome (MS) has been evaluated only in one previous study with contradictory results. The aim of our study was to investigate the association of -55C/T polymorphism of UCP3 gene with MS. DESIGN: A population of 817 obese Caucasian patients was analyzed in a cross-sectional survey. Genotype of UCP3 gene -55C/T was studied. To estimate the prevalence of MS , the definitions of the ATPIII were considered. RESULTS: Five hundred and ninety-four patients (72.7%) had the genotype -55CC (wild group), whereas 223 patients (27.3%) had the genotype -55C/T. Genotype -5TT was not detected. Prevalence of mutant UCP genotypes was similar in patients with MS (75.7% wild genotype and 24.3% mutant genotype) and without MS (69.7% wild genotype and 30.3% mutant genotype). Odds ratio of MS wild vs. mutant genotype was 1.17 CI 95%: 0.99-1.38). Total cholesterol and low density lipoprotein (LDL) cholesterol concentrations were lower in mutant-type group than wild-type group in patients with MS. No differences in other parameters were detected between genotypes in the same group of MS. CONCLUSION: -55C/T UCP polymorphism is not major risk factor for the MS. However, in mutant group of -55CC UCP3 gene in patients with MS, total cholesterol and LDL cholesterol were lower than wild-type patients.
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Luis et al. (2012) conducted a cross-sectional in Metabolic syndrome / Obesity (n=817). -55C/T polymorphism of UCP3 gene vs. Wild-type genotype (-55CC) was evaluated on Metabolic syndrome (OR 1.17, 95% CI 0.99-1.38). The -55C/T polymorphism of the UCP3 gene was not significantly associated with metabolic syndrome (OR 1.17, 95% CI 0.99-1.38 for wild vs. mutant genotype).
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