Key result
The -55CT polymorphism of the UCP3 gene in obese patients was associated with higher C-reactive protein levels (6.9 vs 5.1 mg/dl; p<0.05) but no differences in fat mass or anthropometric parameters.
Why the study?
Does the -55CT polymorphism of the UCP3 gene affect fat distribution and cardiovascular risk factors in obese patients?
Cohort (n=225)
Does the -55CT polymorphism of the UCP3 gene affect fat distribution and cardiovascular risk factors in obese patients?
Absolute Event Rate: 6.9% vs 5.1%
p-value: p=< 0.05
The -55CT polymorphism of the UCP3 gene is associated with higher C-reactive protein levels in obese patients, but not with differences in fat distribution or anthropometric parameters.
BACKGROUND AND AIMS: Some studies have pointed to a role of UCP3 in the regulation of whole-body energy homeostasis and regulation of fat distribution. The aim of our study was to investigate the influence of -55CT polymorphism of UCP3 gene on fat distribution and classical cardiovascular risk factors in obese patients. DESIGN: A population of 225 obese patients was analyzed in a prospective way. A nutritional evaluation was performed. Dietary intake and exercise were recorded. The genotype of UCP3 gene -55CT was studied. RESULTS: 225 patients gave informed consent and were enrolled. 178 (53 males/125 females) (79.1%) had genotype 55CC (wild group) and 47 patients (14 males/33 females) (20.9%) 55CT (mutant group). In the mutant group, resting metabolic rate was higher than in the wild group. However, resting metabolic rate corrected by fat-free mass was similar. No differences were detected in fat mass or other anthropometric parameters. C-reactive protein was higher in the mutant group than in the wild group (5.1 +/- 5.7 vs. 6.9 +/- 6.8 mg/dl; p < 0.05). CONCLUSION: In the mutant group of -55CC UCP3 gene patients, C-reactive protein was higher than in the wild-type patients. However, no differences in anthropometric parameters were detected in either group.
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Luis et al. (2007) conducted a cohort in Obesity (n=225). -55CT polymorphism of UCP3 gene (mutant genotype) vs. 55CC genotype (wild-type) was evaluated on Fat distribution and C-reactive protein levels (p=< 0.05). The -55CT polymorphism of the UCP3 gene in obese patients was associated with higher C-reactive protein levels (6.9 vs 5.1 mg/dl; p<0.05) but no differences in fat mass or anthropometric parameters.
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