Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 6, 2020Journal of Cardiovascular Medicine

Arrhythmic event prediction in patients with heart failure and reduced ejection fraction

View Full Paper
Ask AI
Bookmark
Share

Key result

A clinical score based on comorbidities significantly predicted sustained ventricular arrhythmias in heart failure patients with an ICD (OR 1.92 per point increase; 95% CI 1.40-2.65; P<0.0001).

Why the study?

LVEF has low sensitivity for predicting arrhythmic events in patients with symptomatic heart failure and LVEF 35% or less receiving an ICD, prompting a search for predictors of sustained ventricular arrhythmias.

Does a clinical score based on comorbidities predict sustained ventricular arrhythmias in patients with heart failure and reduced ejection fraction receiving an ICD for primary prevention?

Population

193 patients with chronic heart failure and LVEF less than 35% receiving ICD for primary prevention

Comparison

Predictors of sustained ventricular arrhythmias overall and by heart failure cause (nonischemic vs ischemic)

Design

Single-center retrospective cohort study

Follow-up

Median 1440 days

Authors

GSGloria SantangeloFBFrancesca BursiMNMaria Silvia Negroni

Discussion

Loading...

Member takes

Overview

May aid VA risk stratification in HF-ICD patients; leaves open prospective validation before clinical use.

Study Design

Type

Cohort (n=193)

Multicenter

No

Structured PICO

Does a clinical score based on comorbidities predict sustained ventricular arrhythmias in patients with heart failure and reduced ejection fraction receiving an ICD for primary prevention?

P
Population
193 patients with chronic heart failure and LVEF <35% who received an ICD for primary prevention, followed for a median of 1440 days.
E
Exposure
A clinical score based on comorbidities (hypertension, diabetes, chronic renal failure, atrial fibrillation, chronic obstructive pulmonary disease, NYHA class ≥ III)
O
Outcome
Sustained ventricular arrhythmias (SVAs) detected by the ICDhard clinical

Main Result

Odds Ratio: 1.92 (95% CI 1.4–2.65)

p-value: p=< 0.0001

A simple clinical score based on comorbidities can help predict sustained ventricular arrhythmias in patients with HFrEF receiving an ICD for primary prevention.

Cite This Study

Santangelo et al. (2020) conducted a cohort in chronic heart failure with LVEF <35% (n=193). Clinical score based on comorbidities was evaluated on sustained ventricular arrhythmias (SVAs) (OR 1.92, 95% CI 1.40-2.65, p=< 0.0001). A clinical score based on comorbidities significantly predicted sustained ventricular arrhythmias in heart failure patients with an ICD (OR 1.92 per point increase; 95% CI 1.40-2.65; P<0.0001).

synapsesocial.com/papers/6a745ee78d2049c8dd03208fhttps://doi.org/10.2459/jcm.0000000000001058
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk Stratification for Primary Implantation of a Cardioverter-Defibrillator in Patients With Ischemic Left Ventricular Dysfunction2008 · 533 citations
  2. 2Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure2016 · 1,762 citations
  3. 3Amiodarone or an Implantable Cardioverter–Defibrillator for Congestive Heart Failure2005 · 6,587 citations
  4. 4External Validation of Risk Factors for Malignant Ventricular Arrhythmias in Lamin A/C Mutation Carriers2019 · 22 citations
  5. 5Prospective Randomized Multicenter Trial of Empirical Antitachycardia Pacing Versus Shocks for Spontaneous Rapid Ventricular Tachycardia in Patients With Implantable Cardioverter-Defibrillators2004 · 776 citations