Why the study?
Does insulin infusion stimulate low-density lipoprotein (LDL) degradation in vivo?
Does insulin infusion stimulate low-density lipoprotein (LDL) degradation in vivo?
Insulin stimulates LDL catabolism in vivo, providing a potential physiological mechanism for the reduction of LDL-cholesterol levels observed in intensively treated type I diabetic patients.
May explain LDL reductions with intensive insulin in T1D; hypothesis-generating for CV outcomes, needs prospective confirmation.
The effect of insulin on low-density lipoprotein (LDL) metabolism in vivo was evaluated using the euglycemic insulin clamp technique. In seven subjects, mononuclear cells isolated after a 4-h insulin infusion degraded more 125I-labeled LDL than cells isolated after a saline infusion in six control subjects. In addition, insulin caused the accelerated disappearance of 125I-labeled LDL from plasma in subjects previously injected with autologous 125I-LDL. Infusion of saline had no such effect. These data suggest that insulin, in vivo, stimulates LDL catabolism and could thereby influence LDL cholesterol levels. Insulin-induced stimulation of LDL catabolism could account for the reduction of LDL-cholesterol levels observed in intensively treated type I diabetic patients.
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Mazzone et al. (1984) studied this question.
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