Population
Hamsters infected intracerebrally with scrapie agent
Design
Preclinical
Follow-up
up to 85 to 95 days
Authors
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Animal model data support replication preceding fibrils and disease; hypothesis-generating for prion amyloidoses with no clinical implications yet.
The study confirms that scrapie agent replication precedes scrapie-associated fibril formation and clinical disease, supporting the concept of unconventional virus diseases as virus-induced, organ-specific amyloidoses.
Czub et al. (1988) studied this question.
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