Population
Hamsters infected intraperitoneally with scrapie agent
Design
Preclinical
Follow-up
up to 123 days post-infection
Authors
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Scrapie infectivity precedes SAF detection in hamsters; leaves open viral induction of amyloidosis and requires validation in other models.
The kinetics of scrapie infectivity and SAF accumulation in hamsters suggest a virus-induced amyloidosis of the brain as the cause of disease.
Czub et al. (1986) studied this question.
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