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May 1, 1985Neuropathology and Applied Neurobiology

Pathogenesis of Mouse Scrapie: Dynamics of Vacuolation in Brain and Spinal Cord After Intraperitoneal Infection

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Key result

Intraperitoneal infection with 139A scrapie in mice resulted in grey matter vacuolation first in the thoracic cord, spreading in a caudal to rostral sequence that mirrored the spread of infection.

Authors

SCSoren ColeJohns Hopkins UniversityRKR.H. KimberlinThe Pirbright Institute

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Implication

Highlights early thoracic involvement in peripheral prion models; leaves open generalizability to other strains or species.

PICO

P
Population
Mice (CW) infected intraperitoneally with 139A scrapie to study the sequential development of lesions in the brain and spinal cord.
I
Intervention / Comparator
Intraperitoneal infection with 139A scrapie
O
Primary Outcome
Sequential development of vacuolation in brain and spinal cord

Cite This Study

Cole et al. (1985) studied Scrapie. Intraperitoneal infection with 139A scrapie was evaluated on Sequential development of vacuolation in brain and spinal cord. Intraperitoneal infection with 139A scrapie in mice resulted in grey matter vacuolation first in the thoracic cord, spreading in a caudal to rostral sequence that mirrored the spread of infection.

synapsesocial.com/papers/6a954cdfd002db7cabf593fdhttps://doi.org/10.1111/j.1365-2990.1985.tb00019.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pathogenesis of Mouse Scrapie: Evidence for Spread of Infection from Central to Peripheral Nervous System1983 · 63 citations
  2. 2Virologic and Neurohistologic Findings in Dairy Goats Affected with Natural Scrapie1980 · 120 citations
  3. 3SUBACUTE SPONGIFORM ENCEPHALOPATHY (CREUTZFELDT-JAKOB DISEASE)1978 · 315 citations
  4. 4EXPERIMENTAL KURU IN THE SPIDER MONKEY1975 · 62 citations
  5. 5Natural Infection of Suffolk Sheep with Scrapie Virus1982 · 414 citations