Key result
Intraperitoneal infection with the 139A strain of scrapie in CW mice suggested a centrifugal spread of infection from the central to the peripheral nervous system, where replication was restricted.
The study provides evidence for the centrifugal spread of scrapie infection from the central to the peripheral nervous system in mice, with restricted replication in the peripheral nervous system.
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Hypothesis-generating for centrifugal prion spread in this mouse model; leaves open generalizability to other strains or species.
The onset of replication has been studied in spinal cord, dorsal root ganglia and spinal nerves of CW mice infected intraperitoneally with the 139A strain of scrapie. The patterns obtained suggest a centrifugal spread of infection from central to peripheral nervous systems. Infectivity titres in the peripheral nervous system reached a plateau long before the end of the incubation period, and the maximum titres were much lower than in the central nervous system. This suggests that there is a restriction of replication in the peripheral nervous system similar to that already known in extraneural tissues.
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Kimberlin et al. (1983) studied Scrapie. Intraperitoneal infection with 139A strain of scrapie was evaluated on Infectivity titres in spinal cord, dorsal root ganglia and spinal nerves. Intraperitoneal infection with the 139A strain of scrapie in CW mice suggested a centrifugal spread of infection from the central to the peripheral nervous system, where replication was restricted.
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