What question did this study set out to answer?

Investigate the tissue distribution, replication kinetics, and pathways of spread of the scrapie agent in mice following experimental infection.

February 1, 1967The Journal of Infectious Diseases

Pathogenesis of Scrapie Virus Infection in the Mouse

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Authors

CEC. M. EklundUnited States Public Health Service RKR. C. KennedyNational Institute of Allergy and Infectious Diseases WHW. J. HadlowAnimal and Plant Health Inspection Service

Discussion

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Implication

Experimental animal study demonstrates sequential spread of scrapie through lymphoid tissue before central nervous system invasion, highlighting mechanisms of slow neurodegenerative disease.

Key Points

Investigate the tissue distribution, replication kinetics, and pathways of spread of the scrapie agent in mice following experimental infection.
Inoculated mice subcutaneously or intracerebrally with mouse-adapted scrapie agent.
Assayed infectivity titers sequentially in multiple tissues, including spleen, lymph nodes, thymus, spinal cord, and brain throughout the incubation period.
Demonstrated initial agent replication and accumulation in lymphoid tissues, particularly the spleen and lymph nodes, well before neurological involvement.
Tracked the subsequent spread of infectious titers to the spinal cord and brain, where high titers coincided with progressive histological lesions and fatal neurological symptoms.

Cite This Study

Eklund et al. (1967) studied this question.

synapsesocial.com/papers/6a7140638031ec7bb1dcd9bf https://doi.org/10.1093/infdis/117.1.15

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February 1, 1967The Journal of Infectious Diseases

Pathogenesis of Scrapie Virus Infection in the Mouse

View Full Paper

Ask AI

Bookmark

Authors

CEC. M. EklundUnited States Public Health Service RKR. C. KennedyNational Institute of Allergy and Infectious Diseases WHW. J. HadlowAnimal and Plant Health Inspection Service

Discussion

Member takes

Implication

Experimental animal study demonstrates sequential spread of scrapie through lymphoid tissue before central nervous system invasion, highlighting mechanisms of slow neurodegenerative disease.

Key Points

Investigate the tissue distribution, replication kinetics, and pathways of spread of the scrapie agent in mice following experimental infection.
Inoculated mice subcutaneously or intracerebrally with mouse-adapted scrapie agent.
Assayed infectivity titers sequentially in multiple tissues, including spleen, lymph nodes, thymus, spinal cord, and brain throughout the incubation period.
Demonstrated initial agent replication and accumulation in lymphoid tissues, particularly the spleen and lymph nodes, well before neurological involvement.
Tracked the subsequent spread of infectious titers to the spinal cord and brain, where high titers coincided with progressive histological lesions and fatal neurological symptoms.

Cite This Study

Eklund et al. (1967) studied this question.

synapsesocial.com/papers/6a7140638031ec7bb1dcd9bf https://doi.org/10.1093/infdis/117.1.15

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