July 1, 1969Journal of General Virology

Failure of Interferon to Modify Scrapie in the Mouse

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Why the study?

Does Statolon influence the development or course of scrapie in mice?

Population

18 three-week-old male mice inoculated with scrapie infective material

Comparison

Statolon 0.1 ml of 5% solution injected… vs Six similar mice inoculated intraperitoneally…

Design

Preclinical

Follow-up

7 months

Authors

EFE. J. FieldAt Bristol GJGreta JoyceNorth Tyneside General Hospital AKA.B. KeithNorth Tyneside General Hospital

Discussion

Member takes

Implication

Statolon ineffective against murine scrapie; leaves open interferon role in other prion models without supporting translation.

Structured PICO

Does Statolon influence the development or course of scrapie in mice?

Population

18 three-week-old male mice inoculated with scrapie infective material

Intervention

Statolon (interferon stimulating agent) 0.1 ml of 5% solution injected intraperitoneally one week before scrapie challenge, the next day, and at weekly intervals until the end of the experiment

Comparator

Six similar mice inoculated intraperitoneally with the same scrapie material to serve as controls

Outcome

Development of clinical signs (incubation period and evolution of signs)

Statolon, an interferon stimulating agent, does not modify the incubation period or clinical course of scrapie in mice.

Cite This Study

Field et al. (1969) studied this question.

synapsesocial.com/papers/6a89d18e4c30e1095aec93a6 https://doi.org/10.1099/0022-1317-5-1-149

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Failure of Interferon to Modify Scrapie in the Mouse

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Failure of Interferon to Modify Scrapie in the Mouse

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider