March 1, 1986Journal of General Virology

Prolongation of Scrapie Incubation Period by an Injection of Dextran Sulphate 500 within the Month Before or After Infection

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Population

11 different inbred strains of mice inoculated with scrapie

Comparison

Intraperitoneal injection of dextran sulphate… vs Control mice not receiving DS500 (implied)

Design

Preclinical

Authors

CFChristine FarquharThe Pirbright Institute ADA.G. DickinsonThe Pirbright Institute

Discussion

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Implication

DS500 may mitigate scrapie susceptibility in mice near infection time; leaves open translation to human prion disease prevention.

Structured PICO

Population

11 different inbred strains of mice (BALB/c, BSC, BRVR, C3H, C57BL, IM, LM, MM, RIII, VL and VM) inoculated with scrapie (ME7 or 22A strains)

Intervention

Intraperitoneal injection of dextran sulphate 500 (DS500) at doses of 25 micrograms, 250 micrograms, or 2.5 mg, administered between 4 weeks prior to and 2 months after scrapie inoculation

Comparator

Control mice not receiving DS500 (implied)

Outcome

Scrapie incubation period and susceptibility/survival

Dextran sulphate 500 significantly prolongs the incubation period and reduces susceptibility to scrapie in mice when administered within a month before or after infection.

Cite This Study

Farquhar et al. (1986) studied this question.

synapsesocial.com/papers/6a89d0e00e4958e0bcf7d2cb https://doi.org/10.1099/0022-1317-67-3-463

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Prolongation of Scrapie Incubation Period by an Injection of Dextran Sulphate 500 within the Month Before or After Infection

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Prolongation of Scrapie Incubation Period by an Injection of Dextran Sulphate 500 within the Month Before or After Infection

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider