Why the study?
Does antiserum against scrapie-associated fibrils affect the scrapie incubation period in mice?
Population
Mice inoculated with scrapie-infected mouse brain homogenate
Comparison
Antiserum against a fraction enriched for… vs Phosphate-buffered saline or pre-immune serum
Design
Preclinical
Authors
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Antibodies to SAF do not alter scrapie incubation in mice; leaves open whether other prion targets or delivery methods merit testing.
Does antiserum against scrapie-associated fibrils affect the scrapie incubation period in mice?
Antiserum against scrapie-associated fibrils does not alter scrapie infectivity or incubation period in mice.
Ito et al. (1988) studied this question.
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