Key result
Intraperitoneal scrapie inoculation in newborn mice yields a 1-year latent period before high viral titers.
Why the study?
Scrapie is a slow-virus disease similar to human neurological diseases, but the mechanisms of virus latency and replication timing are unclear.
Scrapie virus can establish a latent state when inoculated in newborn mice, suggesting comparable human slow-virus diseases might result from perinatal infection.
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Supports latent perinatal infection in mice; leaves open applicability to human slow-virus diseases.
Hotchin et al. (1977) studied Scrapie. Intraperitoneal inoculation of scrapie virus particles on day 0 vs. Inoculation from 4 days after birth was evaluated on Virus replication and disease occurrence. Intraperitoneal inoculation of scrapie virus into newborn mice resulted in a 1-year latent period with no detectable replication, followed by high viral titers in the spleen and brain at 18 months.
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