Population
Six models of intraperitoneally injected scrapie, including two Sinc genotypes of mice, three other mouse…
Comparison
Intraperitoneal injection of scrapie agent vs Comparisons between different scrapie models
Design
Preclinical
Follow-up
Up to 482 days
Authors
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Scrapie incubation variability is driven by neural replication kinetics; leaves open translation to human prion disease models.
Differences in incubation periods of scrapie models depend mainly on the rate of replication and spread in the nervous system rather than the lymphoreticular system.
Kimberlin et al. (1988) studied this question.
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