Dextran Sulphate 500 Delays and Prevents Mouse Scrapie by Impairment of Agent Replication in Spleen

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Why the study?

Does dextran sulphate 500 delay or prevent disease in scrapie-infected mice?

Population

Scrapie-infected mice

Design

Preclinical

Follow-up

350 days

Authors

Discussion

Does not support clinical use in humans; leaves open mechanistic studies of dextran sulphate in prion models.

Does dextran sulphate 500 delay or prevent disease in scrapie-infected mice?

Population

Scrapie-infected mice

Intervention

Dextran sulphate (DS) 500 (single or multiple injections)

Outcome

Spleen titres of scrapie agent and central nervous system disease development/lethalityhard clinical

Dextran sulphate 500 significantly delays or prevents scrapie pathogenesis in mice, especially when administered simultaneously with infection.

Ehlers et al. (1984) studied this question.

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