September 1, 1986Antimicrobial Agents and Chemotherapy

Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions

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Population

Adult female Compton White mice

Comparison

Polyanions including HPA-23, dextran sulfate, or… vs Saline-treated control mice

Design

Preclinical

Follow-up

up to 300 days

Authors

RKR.H. KimberlinThe Pirbright Institute CWCarol WalkerUniversity of Oxford

Discussion

Member takes

Implication

May inform preclinical antiprion research; leaves open any human applicability.

Structured PICO

Population

Adult female Compton White mice

Intervention

Polyanions including HPA-23 (e.g., 1-5 mg/day i.p.), dextran sulfate (DS-500, 0.1-2.0 mg i.p. or i.v.), or carrageenan, administered before or after scrapie infection

Comparator

Saline-treated control mice

Outcome

Effective scrapie titer (Log10 LD50 per 0.1 g of brain) and incubation period

Polyanions such as HPA-23 and dextran sulfate significantly suppress scrapie infection in mice, suggesting potential prophylactic or therapeutic strategies for unconventional slow viruses.

Cite This Study

Kimberlin et al. (1986) studied this question.

synapsesocial.com/papers/6a89d1582b29b1e07b92d4f3 https://doi.org/10.1128/aac.30.3.409

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Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider