Key result
Sequential combination therapy with tadalafil, macitentan, and selexipag was administered to a 73-year-old woman with pulmonary arterial hypertension, who died 1 month later.
Why the study?
The number of elderly patients with pulmonary arterial hypertension is increasing, and their characteristics differ from those of younger patients.
Case Report (n=1)
Elderly patients with PAH often have multimorbidities that complicate diagnosis and worsen prognosis, highlighting the need for early right heart catheterization.
Death after triple PAH therapy in one elderly patient warrants caution; hypothesis-generating and leaves open safety questions.
BACKGROUND: There is an increasing number of elderly patients with pulmonary arterial hypertension (PAH), and their characteristics differ from those of young or middle-aged patients with this condition. CASE SUMMARY: A 73-year-old woman with a history of myocardial infarction and cardiovascular risk factors was admitted to the hospital with 2-week exertional dyspnoea. Her initial diagnosis was heart failure with preserved ejection fraction, but the symptoms persisted despite receiving treatment with diuretics. Additional tests showed a significant decrease in diffusing capacity of carbon monoxide and findings suggestive of severe pulmonary hypertension (PH). Contrast-enhanced computed tomography of the chest, and pulmonary angiography, showed no narrowing or obstruction of the pulmonary arteries. Right heart catheterization revealed haemodynamic data implying pre-capillary PH. Her condition gradually deteriorated to World Health Organization functional class IV, and sequential combination therapy with tadalafil, macitentan, and selexipag was initiated with a PAH diagnosis; however, she died 1 month later. Pathological findings in autopsy were consistent with PAH, and some parts of the lungs revealed the presence of obstructive and interstitial lung disease. DISCUSSION: The majority of elderly patients with PAH might have multimorbidity. However, there is no specific treatment strategy. It is associated with diagnostic delay and worse prognosis; therefore, early suspicion and comprehensive tests, including right heart catheterization, are essential for better management.
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Yokose et al. (2021) conducted a case report in Pulmonary arterial hypertension (n=1). Sequential combination therapy with tadalafil, macitentan, and selexipag was evaluated. Sequential combination therapy with tadalafil, macitentan, and selexipag was administered to a 73-year-old woman with pulmonary arterial hypertension, who died 1 month later.
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