March 1, 1990Journal of VirologyOpen Access

An intragenic revertant of a poliovirus 2C mutant has an uncoating defect

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Population

Poliovirus 2C mutant (2C-31) and its revertants (2C-31R1, 2C-31R3)

Comparison

Temperature shifts, cDNA cloning, and… vs Parental mutant 2C-31

Design

Preclinical

Authors

Discussion

Supports expanded 2C targeting in antivirals; leaves open translation from animal models to human disease.

Population

Poliovirus 2C mutant (2C-31) and its revertants (2C-31R1, 2C-31R3)

Intervention

Temperature shifts (39°C vs 32°C), cDNA cloning, and mix-and-match recombination

Comparator

Parental mutant 2C-31

Outcome

Viral growth, RNA synthesis, and virion uncoating at different temperatures

Protein 2C of poliovirus plays a role in determining virion structure and uncoating, in addition to its known role in viral RNA synthesis.

Li et al. (1990) studied this question.

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