Why the study?
What are the comparative effects of verapamil and propranolol on contractility, frequency, coronary flow, and oxygen consumption in isolated rabbit hearts?
Population
Isolated rabbit hearts, retrogradely perfused in a re-circulatory system
Design
Preclinical
Authors
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Distinct effects in isolated hearts caution against clinical extrapolation; leaves open translation to human physiology.
What are the comparative effects of verapamil and propranolol on contractility, frequency, coronary flow, and oxygen consumption in isolated rabbit hearts?
Verapamil and propranolol demonstrate distinct pharmacological profiles regarding coronary flow, contractility, and chronotropy in an isolated rabbit heart model.
Magnussen et al. (1974) studied this question.
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