Key result
Verapamil selectively depressed contractility in ischemic myocardium in 5/5 dogs without altering normal myocardium, whereas propranolol depressed contractile function in both.
Why the study?
Does verapamil selectively depress contractility in ischemic myocardium compared to propranolol in open-chest dogs?
Population
Open-chest dogs with partially ischemic myocardium and normal myocardium
Comparison
Verapamil vs Propranolol (0.01-1.0 mg/kg)
Design
Preclinical
Authors
Loading...
Caution against clinical use of verapamil for selective ischemic protection; leaves open human translation of this canine model.
Does verapamil selectively depress contractility in ischemic myocardium compared to propranolol in open-chest dogs?
Verapamil selectively depresses contractility in ischemic myocardium without affecting normal myocardium, unlike propranolol which depresses both, suggesting a potential mechanism to reduce myocardial oxygen demand and ischemic injury.
Smith et al. (1976) studied Myocardial ischemia (n=7). Verapamil vs. Propranolol was evaluated on Regional contractile function. Verapamil selectively depressed contractility in ischemic myocardium in 5/5 dogs without altering normal myocardium, whereas propranolol depressed contractile function in both.