Why the study?
Does aging alter the intrinsic function or structure of Na+ currents in canine atrial cells?
Population
Right and left atrial cells from two groups of dogs: adult and aged, all in normal sinus rhythm
Comparison
Aging (aged dogs >8 yr) vs Adult dogs
Design
Preclinical
Authors
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May link subtle Na channel kinetics to age-related AF risk in canines; leaves open human translation and therapeutic relevance.
Does aging alter the intrinsic function or structure of Na+ currents in canine atrial cells?
Aging in canine atrial cells does not alter sodium current density or channel structure but causes subtle kinetic changes that enhance use dependence, which may relate to age-associated atrial fibrillation.
Baba et al. (2006) studied this question.
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