Why the study?
Does simultaneous transduction with MyoD and connexin43 produce excitable, electrically coupled cells from human dermal fibroblasts?
Population
Human dermal fibroblasts (HDFs)
Comparison
Simultaneous transduction with high-titer… vs Transduction with MyoD-encoding vector alone
Design
Preclinical
Authors
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Offers proof-of-concept for fibroblast reprogramming; leaves open translation to conduction repair in vivo.
Does simultaneous transduction with MyoD and connexin43 produce excitable, electrically coupled cells from human dermal fibroblasts?
Human dermal fibroblasts can be genetically modified using MyoD and connexin43 to produce excitable, electrically coupled cells, demonstrating proof-of-concept for gene-based repair of cardiac conduction defects.
Kizana et al. (2005) studied this question.
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