Why the study?
Does the A2-OS interval during exercise indicate left atrial mean pressure and severity of stenosis in patients with mitral stenosis?
Does the A2-OS interval during exercise indicate left atrial mean pressure and severity of stenosis in patients with mitral stenosis?
The A2-OS interval during exercise is an effective indicator of left atrial mean pressure and can differentiate mild from moderate or severe mitral stenosis.
Answers are grounded in this paper and cite their sources.
Exercise A2-OS changes may track LA pressure in mitral stenosis; hypothesis-generating for noninvasive severity assessment.
Cardiac catheterization and phonocardiography data were obtained from patients with mitral stenosis at rest and during exercise. There was a linear relationship between the percentage decrease of the interval from closure of the aortic valve to the mitral valve opening snap (A2-OS) and the percentage increase [see figure in the PDF file] of the left atrial mean pressure from rest to exercise. The duration of the A2-OS interval was an effective indicator of the level of the left atrial mean pressure during exercise. The duration of the A2-OS interval during exercise allowed separation of patients with mild stenosis from those with moderate or severe stenosis but could not be used to distinguish moderate stenosis from severe stenosis.
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Delman et al. (1966) studied this question.
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