Key result
The intervals from Q to mitral valve closure and Q to peak dA/dt were significantly correlated in normal subjects (r=0.79), a relationship that was lost in patients with coronary artery disease and raised end-diastolic pressure.
Why the study?
Does the timing of mitral valve closure relative to the apexcardiogram identify characteristic alterations in patients with heart disease compared to normal subjects?
Population
25 normal subjects and 88 patients with heart disease
Comparison
Simultaneous M mode echocardiograms… vs Normal subjects vs. patients with heart disease
Design
Cross-sectional
Authors
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Disrupted Q-MVC and Q-peak dA/dt correlation in CAD with raised EDP may indicate altered LV mechanics; leaves open noninvasive apexcardiographic assessment.
Cross-Sectional (n=113)
No
Does the timing of mitral valve closure relative to the apexcardiogram identify characteristic alterations in patients with heart disease compared to normal subjects?
Effect estimate: r = 0.79
The predictable relationship between mitral valve closure and the onset of left ventricular mechanical systole in normal subjects is altered in specific heart diseases, such as coronary artery disease with raised end-diastolic pressure.
Šmalcelj et al. (1985) conducted a cross-sectional in Heart disease (coronary artery disease and valvular disease) (n=113). Simultaneous echocardiographic and apexcardiographic measurement of early systolic events vs. Normal subjects vs patients with heart disease was evaluated on Correlation between the interval from Q wave to mitral valve closure (Q-MVC) and Q to peak rate of rise of the apexcardiogram (Q to peak dA/dt) (r = 0.79). The intervals from Q to mitral valve closure and Q to peak dA/dt were significantly correlated in normal subjects (r=0.79), a relationship that was lost in patients with coronary artery disease and raised end-diastolic pressure.
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