Population
Intact dogs with radiopaque markers sutured to the mitral valve cusps and annulus 7-124 weeks prior to the…
Design
Preclinical
Authors
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Challenges traditional isovolumic timing assumptions in canines; leaves open translation to human hemodynamics and clinical definitions.
In an intact canine model, mitral valve opening precedes diastolic pressure crossover and closure follows atrial-ventricular crossover, suggesting that ventricular isovolumic contraction and relaxation periods may be shorter than traditionally assumed.
Tsakiris et al. (1978) studied this question.
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