May 1, 1973Circulation

Temporal Relation of the First Heart Sound to Closure of the Mitral Valve

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Population

Open-chest dogs

Design

Preclinical

Authors

SLShlomo LaniadoTel Aviv University EYEdward L. YellinJerusalem College of Technology HMHyman I. MillerSUNY Downstate Health Sciences University

Discussion

Member takes

Implication

Extends animal-model insights into S1 timing; leaves open human validation and clinical correlation.

Structured PICO

Population

Open-chest dogs

Intervention

Measurement of phasic flow across the mitral valve using a supraannular electromagnetic flow probe and timing of valve closure via synchronized cinefluorogram of radio-opaque valve cusps

Outcome

Temporal relation between the major components of the first heart sound (S1) and cessation of mitral flow, closure of the valve, and time of peak rate of rise of left ventricular pressure (peak LV dP/dt)surrogate

This physiological study demonstrates that the first heart sound is produced simultaneously with the cessation of mitral flow and mitral valve closure, which occurs 20-40 msec after the onset of systole due to flow inertia.

Cite This Study

Laniado et al. (1973) studied this question.

synapsesocial.com/papers/6a8c7d35e24e8f4e5c666387 https://doi.org/10.1161/01.cir.47.5.1006

View Full Paper

Ask AI

Bookmark

Temporal Relation of the First Heart Sound to Closure of the Mitral Valve

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Temporal Relation of the First Heart Sound to Closure of the Mitral Valve

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider