Key result
Surgical decentralization or spinal cord stimulation reduced ischemia-induced norepinephrine release and decreased the risk of ventricular fibrillation from 38% in controls to 8% and 11%, respectively.
Why the study?
The study was conducted to define the mechanism by which cardiac neuraxial decentralization or spinal cord stimulation reduces ischemia-induced ventricular fibrillation.
Does cardiac neuraxial decentralization or spinal cord stimulation reduce ischemia-induced norepinephrine release and ventricular fibrillation in a canine model?
Population
Anesthetized canines
Comparison
Intact neuraxes vs stellate ganglia decentralization vs ICN decentralization vs preemptive SCS (T1-T3)
Design
Animal experimental study
Authors
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Neuromodulation may mitigate ischemia-related VF; hypothesis-generating and should not change practice pending clinical validation.
Does cardiac neuraxial decentralization or spinal cord stimulation reduce ischemia-induced norepinephrine release and ventricular fibrillation in a canine model?
Absolute Event Rate: 8% vs 38%
p-value: p=<0.05
Cardiac sympathectomy and spinal cord stimulation attenuate reflex-mediated norepinephrine release during acute myocardial ischemia, thereby reducing the risk of ventricular fibrillation.
Ardell et al. (2019) studied Myocardial ischemia-induced ventricular fibrillation (n=34). Cardiac neuraxial decentralization or spinal cord stimulation (SCS) vs. Intact neuraxes (untreated controls) was evaluated on Incidence of ventricular fibrillation (VF) during transient coronary artery occlusion (p=<0.05). Surgical decentralization or spinal cord stimulation reduced ischemia-induced norepinephrine release and decreased the risk of ventricular fibrillation from 38% in controls to 8% and 11%, respectively.
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